Laboratory of Physiology and Pathophysiology of Adipose Tissue

Research projects:

• De novo lipogenesis in adipose tissue, including the synthesis of insulin-sensitizing PAHSA
• Relationship between adipose tissue and the lymphatic system

Department of Pathophysiology at the Third Faculty of Medicine is involved in the study of various aspects of de novo lipogenesis in adipose tissue, including the synthesis of insulin-sensitizing PAHSA, adipose tissue-liver interactions in response to starvation, as well as the study of lipolysis and secretory properties of adipose tissue in patients with pancreatic cancer. Another research topic is the relationship between adipose tissue and the lymphatic system, i.e., addressing the question of how adipocytes affect lymphatic endothelial function and, vice versa, how various efficiency of lymphatic drainage affects the expansion of individual fat depots.

Our group is also the Czech half of the Czech-French Obesity Clinical Research Laboratory, under the leadership of Prof. Štich (3rd Faculty of Medicine) and Prof. Langin (INSERM). The lab is supported by a number of national grants and H2020 grant.

Selected publications

• KOC, M., WALD, M., VARALIOVA, Z., ONDRUJOVA, B., CIZKOVA, T., BRYCHTA, M., KRACMEROVA, J., BERANOVA, L., PALA, J., SRAMKOVA, V., SIKLOVA, M., GOJDA, J. & ROSSMEISLOVA, L. 2021. Lymphedema alters lipolytic, lipogenic, immune and angiogenic properties of adipose tissue: a hypothesis-generating study in breast cancer survivors. Sci Rep, 11,
• ČÍŽKOVÁ, T., ŠTĚPÁN, M., DAĎOVÁ, K., ONDRŮJOVÁ, B., SONTÁKOVÁ, L., KRAUZOVÁ, E., MATOUŠ, M., KOC, M., GOJDA, J., KRAČMEROVÁ, J., ŠTICH, V., ROSSMEISLOVÁ, L. & ŠIKLOVÁ, M. 2020. Exercise training reduces inflammation of adipose tissue in the elderly: cross-sectional and randomized interventional trial. The Journal of Clinical Endocrinology & Metabolism.

Selected grants

• 2020-2026: TheraLymph –Gene Therapy to restore lymphatic flow lymphedema
• H2020 SC1-BHC-2021-2024: Novel approaches to enhance insulin-sensitizing effects of exercise: targeting PAHSA metabolism ETAPA
• Czech Health Research Council project NU21-01-00469

Team leader & members

• Dr. Lenka Rossmeislová
• Dr. Michaela Šiklová
• Dr. Michal Koc
• Dr. Jana Neubert
• Ezequiel Harnichar (postdoc)
• Zuzana Varaliová (PhD student)
• Marek Wilhelm (PhD student)
• Viktor Šebo, MD (PhD student)

Contact

Charles University
Third Faculty of Medicine
Mgr. Lenka Rossmeislová, Ph.D.
E: lenka.rossmeislova@lf3.cuni.cz

More information

https://www.lf3.cuni.cz/3LFEN-677.html

We have an interest in motivated post graduate and master students, who are interested to contribute to translational research based on the use of human cells and tissue samples under the guidance of experienced lab workers in a friendly atmosphere.

If you are interested, please send us your motivation letter and brief CV.

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