Gynecologic Oncology Clinical Research Group

The research activities of the Gynecologic Oncology Clinical Research Group of the Department of Obstetrics and Gynecology of the First Faculty of Medicine and General Teaching Hospital in Prague are focused on the diagnosis and management of patients with gynaecological malignancies, including vulvar, vaginal, cervical, endometrial, ovarian and primary peritoneal cancers, uterine sarcomas, and rare tumours. Through collaborative clinical trials led by the research group the main aim is to improve patients’ oncological outcome and their quality of life. It also strives to broaden the knowledge of the causal biology and mechanisms of these diseases.

The results of the group´s activities have contributed to increase the level of standard-of-care of gynaecological cancer management.

The Group is a founding member of the Central and Eastern European Gynecological Oncology Group (CEEGOG) and also a member of European Network of Gynaecological Oncological Trial groups (ENGOT).

Team leader & members

• Prof. David Cibula, MD, PhD (Team leader)
• Prof. Jiří Sláma, MD PhD (Principal investigator)
• Prof. Daniela Fischerová, MD, PhD (Principal investigator)
• Filip Frühauf, MD, PhD (Senior Research fellow)
• Roman Kocián, MD, PhD (Senior Research fellow)
• Lukáš Dostálek, MD, PhD (Senior Research fellow)
• Anna Germanová, MD, PhD (Senior Research fellow)
• Martina Borčinová, PhD (Senior Research fellow)
• Alexandra Mayer, PhD (Senior Research fellow)

Main ongoing academic clinical trials: A lead role

Personalisation of surgical treatment of cervical cancer:

• SENTIX – Sentinel lymph node in cervical cancer. An international prospective cohort study.
• CERVANTES – Adjuvant treatment following radical surgery in intermediate-risk cervical cancer patients. An international prospective randomized trial.

Diagnostics and clinical staging:

• ISAAC – Imaging Study on Advanced ovarian Cancer. A prospective cohort international study.
• CANNES – Imaging study on lymph node staging in cervical cancer. A prospective, multicentre cohort study.
• VITA – Vulvar International Tumor Analysis – a implementation of standardized methodology and terms in lymph nodes staging in vulvar cancer (international interobserver study)

Prehabilitation in patients with ovarian cancer and endometrial cancer:

• PHOCUS – Prehabilitation in patients with gynaecological cancer planned for postponed surgical management. A prospective multicentre randomised trial.

Management of precancerous lesions:

• RECER – Regression of cervical precancerous lesions and connected risk factors. Prospective observational cohort study.

Contact

Charles University
Third Faculty of Medicine
E: Daniela.fischerova@vfn.cz

More information

https://www.lf3.cuni.cz/3LFEN-677.html

The Gynecologic Oncology Clinical Research Group provides opportunities for PhD students with background both in medicine and natural sciences.

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